HCID 66812670, compound → HCID 59395815, compound

HRID 1097723Notes

Reaction equation

HRID 1097723 reaction equation
[Cl:1][C:2]1[N:10]([CH2:11][CH:12]=[CH2:13])[C:9]2[C:8](=[O:14])[N:7]([CH2:15][CH2:16][CH2:17][C:18]3ON=C(CC4C=CC(F)=CC=4F)N=3)[C:6](=[O:32])[NH:5][C:4]=2[N:3]=1.ClC1[N:42]([CH2:43][CH:44]=[CH2:45])[C:41]2[C:40](=O)N(CCCC(OCC)=O)[C:38](=[O:55])[NH:37][C:36]=2[N:35]=1>>[Cl:1][C:2]1[N:10]([CH2:11][CH:12]=[CH2:13])[C:9]2[C:8](=[O:14])[N:7]([CH2:15][CH2:16][CH2:17][CH2:18][C:38]3[O:55][N:35]=[C:36]([C:41]4[CH:40]=[CH:45][CH:44]=[CH:43][N:42]=4)[N:37]=3)[C:6](=[O:32])[NH:5][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 66812670HCID 66812670, compoundHCID 66813023HCID 66813023, compound

Product 1

HCID 59395815HCID 59395815, compound

Procedure

Similarly prepared was 8-chloro-1-(3-{3-[(2,4-difluorophenyl)methyl]-1,2,4-oxadiazol-5-yl}propyl)-7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dione using ethyl 4-[8-chloro-2,6-dioxo-7-(2-propen-1-yl)-2,3,6,7-tetrahydro-1H-purin-1-yl]butanoate.

Workup

  1. customSimilarly prepared

Sources & evidence

ORD record
ord-f95bbee2e7f64edaa42d8d98ebaf6363
Source dataset
uspto-grants-2012_03
Patent number
US08143264B2

Reaction notes

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