8-Chloro-1-(5-{5-[(3,4-dichlorophenyl)methyl]-2H-tetrazol-2-yl}pentyl)-3-pentyl-3,7-dihydro-1H-purine-2,6-dione → HCID 178446221, compound

HRID 1097730Notes

Reaction equation

HRID 1097730 reaction equation
[Cl:1][C:2]1[NH:10][C:9]2[C:8](=[O:11])[N:7]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]N3N=NC(CC4C=CC(Cl)=C(Cl)C=4)=N3)[C:6](=[O:31])[N:5]([CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])[C:4]=2[N:3]=1.[Cl:37][C:38]1[CH:43]=[CH:42][C:41]([C:44]2[NH:48][N:47]=C(CCCO)C=2)=[CH:40][CH:39]=1>>[Cl:1][C:2]1[NH:10][C:9]2[C:8](=[O:11])[N:7]([CH2:12][CH2:13][CH2:14][C:15]3[CH:16]=[C:44]([C:41]4[CH:42]=[CH:43][C:38]([Cl:37])=[CH:39][CH:40]=4)[NH:48][N:47]=3)[C:6](=[O:31])[N:5]([CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])[C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 593956058-Chloro-1-(5-{5-[(3,4-dichlorophenyl)methyl]-2H-tetrazol-2-yl}pentyl)-3-pentyl-3,7-dihydro-1H-purine-2,6-dioneHCID 178520418HCID 178520418, compound

Product 1

HCID 178446221HCID 178446221, compoundYield 30%

Procedure

Prepared as with 8-chloro-1-(5-{5-[(3,4-dichlorophenyl)methyl]-2H-tetrazol-2-yl}pentyl)-3-pentyl-3,7-dihydro-1H-purine-2,6-dione (Comparative Example C) using 3-[5-(4-chlorophenyl)-1H-pyrazol-3-yl]-1-propanol. The final product material was washed with ether to yield the title compound as a cream solid (30%).

Workup

  1. washThe final product material was washed with ether

Sources & evidence

ORD record
ord-4d644d8bbf634cdc9699b03ce92d0b7b
Source dataset
uspto-grants-2012_03
Patent number
US08143264B2

Reaction notes

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