HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-(2-(Piperidin-1-YL)ethyl)-1H-imidazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Piperidine, 1-(2-chloroethyl)-, hydrochloride | HCID 74826 | — |
| Reactant | Bis(2-amino-1H-imidazole) sulphate | HCID 135136 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(2-(Piperidin-1-YL)ethyl)-1H-imidazol-2-amine | HCID 53402474 | 22.6% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
2-Aminoimidazole monosulfate (500 mg, 1.89 mmol) and potassium carbonate (580 mg, 4.16 mmol) were suspended in DMF (2 mL) and chloroethyl piperidine mono hydrochloride (766 mg, 4.16 mmol) was added. The reaction was heated at 100° C. for 2.5 hours before being cooled to room temperature and filtered. The filtrate was concentrated and purified by column chromatography (95:4.5:0.5 dichloromethane:methanol:aqueous ammonia) and the product was isolated as a brown oil (83 mg, 11%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143268B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-11c38ac03d9346e0bdd95b1877905f82 |
| Source note | uspto-grants-2012_03 |