反应详情

温度

70 °C

The mixture of 3-phenylamino-propionic acid (1.22 g, 7.39 mmol) in Eaton's reagent (40 mL) is stirred at 70° C. for overnight. The resulting mixture is poured into ice and basified by the slow addition of NaOH (50%) solution. The basified mixture is extracted with ethyl acetate and washed by brine, and dried over anhydrous sodium sulfate. After concentration, the residue is purified by flash chromatography, and gives the title compound (0.5 g, 46.3% yield).

1. additionThe resulting mixture is poured into ice
2. extractionThe basified mixture is extracted with ethyl acetate
3. washwashed by brine
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationAfter concentration
6. customthe residue is purified by flash chromatography