HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium trimethylsilanolate → 6-Chloro-1-methylcarbamoylmethyl-1H-indole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium trimethylsilanolate | HCID 23672319 | — |
| Reactant | 2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide | HCID 66744288 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 6-Chloro-1-methylcarbamoylmethyl-1H-indole-3-carboxylic acid | HCID 59756702 | 27% |
Reaction Steps
2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide was suspensed in DCE and treated with (2.2 eq.) of sodium trimethylsilanolate. After shaking at room temperature for 20 min, the mixture was concentrated in vacuo and purified by prep. HPLC to give the title compound in 27% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143281B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-2a9301d5f3ce4303a72a68cdcb526ac4 |
| Source note | uspto-grants-2012_03 |