HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 24987658, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Chloro-N,N-diethylacetamide | HCID 16844 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 24991356 | HCID 24991356 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 24987658 | HCID 24987658 | — |
Reaction Steps
A solution of 1-[1-(6-chloro-1H-indole-3-carbonyl)-piperidin-4-yl]-1,3-dihydroindol-2-one (1 eq) in dry DMF was treated with NaH (1.1 eq) at RT for 15 mins and then a solution of 2-chloro-N,N-diethyl-acetamide (3.3 eq) and triethylamine (3.3 eq) in three portions and the mixture heated to 60° C. for 6 h. Concentration and purification by prep HPLC gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143281B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-fea06ba1fd4d4e18875f3fd5dc02ccc7 |
| Source note | uspto-grants-2012_03 |