HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 24987664, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 66810929 | HCID 66810929 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 24987664 | HCID 24987664 | — |
Reaction Steps
A solution of 1-{1-[1-(2-amino-ethyl)-6-chloro-1H-indole-3-carbonyl]-piperidin-4-yl}-1,3-dihydro-indol-2-one (1 eq) in dry CH2Cl2 was treated with methanesulfonyl chloride (1.1 eq) and triethylamine at RT for 15 h. Quenching with H2O and extraction into CH2Cl2 followed by concentration and purification by prep HPLC gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143281B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-5ba68c8763854af789b547cb1fabbf34 |
| Source note | uspto-grants-2012_03 |