3-(Chloromethyl)-1,2,4-oxadiazole → 3-[2-Chloro-4-([1,2,4]oxadiazol-3-ylmethoxy)-phenyl]-1,1,1-trifluoro-2-(5-methyl-pyrazin-2-yl)-butan-2-ol

HRID 1097887Notes

Reaction equation

HRID 1097887 reaction equation
Cl[CH2:2][C:3]1[N:7]=[CH:6][O:5][N:4]=1.[Cl:8][C:9]1[CH:10]=[C:11]([OH:30])[CH:12]=[CH:13][C:14]=1[CH:15]([CH3:29])[C:16]([OH:28])([C:21]1[CH:26]=[N:25][C:24]([CH3:27])=[CH:23][N:22]=1)[C:17]([F:20])([F:19])[F:18]>>[Cl:8][C:9]1[CH:10]=[C:11]([O:30][CH2:2][C:3]2[N:7]=[CH:6][O:5][N:4]=2)[CH:12]=[CH:13][C:14]=1[CH:15]([CH3:29])[C:16]([C:21]1[CH:26]=[N:25][C:24]([CH3:27])=[CH:23][N:22]=1)([OH:28])[C:17]([F:18])([F:20])[F:19]

Participants

3

Reactant 2

HCID 27357653-(Chloromethyl)-1,2,4-oxadiazoleHCID 574212313-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol

Product 1

HCID 574212353-[2-Chloro-4-([1,2,4]oxadiazol-3-ylmethoxy)-phenyl]-1,1,1-trifluoro-2-(5-methyl-pyrazin-2-yl)-butan-2-ol

Procedure

The title compound was prepared in analogy to Example 74 from 3-(chloromethyl)-1,2,4-oxadiazole and 3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol (Example 72). MS (m/e)=429.3 (MH+).

Sources & evidence

ORD record
ord-ab107e31d98d471bb0c9d1a3abc2f6fd
Source dataset
uspto-grants-2012_03
Patent number
US08143280B2

Reaction notes

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