HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-1-methyl-2-pyrazolo[1,5-a]pyridin-3-yl-propyl)-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | HCID 57421255 | HCID 57421255 | — |
| Product | 3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-1-methyl-2-pyrazolo[1,5-a]pyridin-3-yl-propyl)-phenol | HCID 25254447 | — |
Reaction Steps
The title compound was prepared in analogy to Example 72 from 3-(2-chloro-4-methoxy-phenyl)-1,1,1-trifluoro-2-pyrazolo[1,5-a]pyridin-3-yl-butan-2-ol (Example 109) by treatment with aqueous HBr. MS (m/e)=371.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143280B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-3d2e093e28b24923b06de6831cbfcd09 |
| Source note | uspto-grants-2012_03 |