Diisobutylaluminum hydride → 3-(2-Chloro-4-hydroxymethyl-phenyl)-2-(2-chloro-pyridin-4-yl)-1,1,1-trifluoro-butan-2-ol

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Reaction Conditions

Reaction Steps

3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-benzoic acid methyl ester (488 mg, Example 135) was dissolved in CH2Cl2 under argon. The solution was cooled to −15° C. in an ice/salt bath and a solution of DIBAL-H (1M in CH2Cl2, 3 mL) was added drop wise. Stirring was continued and the mixture was allowed to warm to 0° C. over a period of 2 hours. The mixture was then poured into ice/water and extracted with ethyl acetate. The organic extracts were washed with brine, dried over Na2SO4 and evaporated. The residue was purified by flash chromatography (silica gel, gradient of ethyl acetate in heptane) to give the title compound as a colorless solid (200 mg). MS (m/e)=380.1 (MH+).

Provenance & Evidence