HRID10979

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(Nc1cnc2n(c1=O)C(Cc1ccccc1)(C(=O)O)CC2)OCc1ccccc1

HCID21979693

未命名化合物

HCID145832046

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NC(=N)c1ccc(CNC(=O)C2(Cc3ccccc3)CCc3ncc(NC(=O)OCc4ccccc4)c(=O)n32)cc1

HCID145857196

未命名化合物

PROCEDURE

实验过程

According to the procedure for the preparation of intermediate 19c, intermediate 21b (50 mg, 0.119 mmol) was coupled with [(4-aminomethyl-phenyl)-imino-methyl]-carbamic acid tert-butyl ester to afford 77 mg (quantitative) of intermediate 21c.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-012f6202a1704b24b330c77a049c3fbc
来源数据集: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07094783B2
来源说明: uspto-grants-2006_08

反应 SMILES

[CH2:1]([C:8]1([C:29]([OH:31])=O)[N:12]2[C:13](=[O:28])[C:14]([NH:17][C:18]([O:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[O:19])=[CH:15][N:16]=[C:11]2[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:32]([O:36][C:37](=[O:49])[NH:38][C:39]([C:41]1[CH:46]=[CH:45][C:44]([CH2:47][NH2:48])=[CH:43][CH:42]=1)=[NH:40])([CH3:35])([CH3:34])[CH3:33]>>[CH2:21]([O:20][C:18](=[O:19])[NH:17][C:14]1[C:13](=[O:28])[N:12]2[C:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)([C:29](=[O:31])[NH:48][CH2:47][C:44]3[CH:45]=[CH:46][C:41]([C:39]([NH:38][C:37]([O:36][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:49])=[NH:40])=[CH:42][CH:43]=3)[CH2:9][CH2:10][C:11]2=[N:16][CH:15]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1