2-(2,4-Dichloro-phenyl)-propionaldehyde → 2-(2,4-dichloro-phenyl)-1-[1-(4-methoxy-phenyl)-1H-indazol-5-yl]-propan-1-ol

Participants

Role	Name	HCID	Charge
Reactant	2-(2,4-Dichloro-phenyl)-propionaldehyde	HCID 20521728	—
Reactant	5-Bromo-1-(4-methoxy-phenyl)-1H-indazole	HCID 57421351	—
Product	2-(2,4-dichloro-phenyl)-1-[1-(4-methoxy-phenyl)-1H-indazol-5-yl]-propan-1-ol	HCID 66813347	—

Reaction Steps

In analogy to Example 186, 5-bromo-1-(4-methoxy-phenyl)-1H-indazole was reacted with 2-(2,4-dichloro-phenyl)-propionaldehyde to give 2-(2,4-dichloro-phenyl)-1-[1-(4-methoxy-phenyl)-1H-indazol-5-yl]-propan-1-ol which was oxidized to 2-(2,4-dichloro-phenyl)-1-[1-(4-methoxy-phenyl)-1H-indazol-5-yl]-propan-1-one and converted further to the title compound. Off-white foam. MS (m/e)=495.1 [M+H+].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08143280B2
Source dataset	uspto-grants-2012_03
ORD ID	ord-4deb0a81a2134bcc8a7518a6daf4d911
Source note	uspto-grants-2012_03