反应详情

温度

0 °C

To a solution of 5-[2-(2,4-dichloro-phenyl)-acetyl]-1H-pyridin-2-one (800 mg) in CH2Cl2 (2.8 ml) was added N,N,N′N′-tetramethyldiaminomethane (896 mg). The mixture was cooled to 0° C. and acetic acid anhydride (0.64 ml) was added. The mixture was stirred at 0° C. for 10 min and at room temperature for 4 h. The solvent was evaporated under reduced pressure. The residue was dissolved in EtOAc and washed with water. The organic phase was concentrated to dryness to give the title compound (857 mg) as a light brown solid that was used for the next step without further purification. MS (m/e, ISP neg. ion)=291.9 [M−H+].

1. customThe solvent was evaporated under reduced pressure
2. dissolutionThe residue was dissolved in EtOAc
3. washwashed with water
4. concentrationThe organic phase was concentrated to dryness