反应详情

Palladium (10% on Carbon) (25.5 mg, 0.24 mmol) was added to (2S)-2-(1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)-3-methoxy-N-(5-methylpyridin-2-yl)propanamide (Example 3) (105 mg, 0.24 mmol) in methanol (2.5 mL) at ambient temperature under nitrogen. This was then purged with hydrogen and the resulting solution was stirred at ambient temperature for 24 hours. The mixture was filtered through celite and evaporated. The residue was purified by flash silica chromatography eluting with 0 to 100% EtOAc in isohexane to afford (S)-3-methoxy-N-(5-methylpyridin-2-yl)-2-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)propanamide (20.0 mg, 20.7%).

1. customThis was then purged with hydrogen
2. filtrationThe mixture was filtered through celite
3. customevaporated
4. customThe residue was purified by flash silica chromatography
5. washeluting with 0 to 100% EtOAc in isohexane