HCID 57504487, compound → HCID 59279487, compound

HRID 1098010Notes

Reaction equation

HRID 1098010 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]2[N:8]([C:11]3[C:16]([CH3:17])=[N:15][CH:14]=[CH:13][N:12]=3)[N:9]=[CH:10][C:3]=12.[CH:18]1([O:22][CH2:23][C@H:24]([OH:35])[C:25]([NH:27][C:28]2[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][N:29]=2)=[O:26])[CH2:21][CH2:20][CH2:19]1>>[CH:18]1([O:22][CH2:23][C@H:24]([O:35][C:2]2[C:3]3[CH:10]=[N:9][N:8]([C:11]4[C:16]([CH3:17])=[N:15][CH:14]=[CH:13][N:12]=4)[C:4]=3[N:5]=[CH:6][N:7]=2)[C:25]([NH:27][C:28]2[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][N:29]=2)=[O:26])[CH2:19][CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 57504487HCID 57504487, compoundHCID 59279453HCID 59279453, compound

Product 1

HCID 59279487HCID 59279487, compound

Procedure

Prepared using an analogous procedure to that described for Example 106 using 4-Chloro-1-(3-methylpyrazin-2-yl)-1H-pyrazolo[3,4-d]pyrimidine (Intermediate I4) with (S)-3-cyclobutoxy-2-hydroxy-N-(5-methylpyridin-2-yl)propanamide (Intermediate U1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-65a2b1da795f42c8be7a20201279cf98
Source dataset
uspto-grants-2012_03
Patent number
US08143263B2

Reaction notes

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