Acetyl chloride → 3-acetamido-2-hydroxy-N-(4-methyl-1,3-thiazol-2-yl)propanamide

Participants

Reaction Steps

Tetrabutylammoniumfluoride (0.28 mL, 1M in THF, 0.28 mmol) was added to a stirred solution of 9H-fluoren-9-ylmethyl (2-{[tert-butyl(dimethyl)silyl]oxy}-3-[(4-methyl-1,3-thiazol-2-yl)amino]-3-oxopropyl)carbamate (Step 2) (0.10 g, 0.186 mmol) in THF (5 mL). The reaction mixture was kept at ambient temperature for 3 hrs before DIPEA (0.036 g, 0.28 mmol) and acetyl chloride (0.018 g, 0.22 mmol) were added. The reaction mixture was stirred for another 3 hrs at ambient temperature and water (1 mL) was added and the reaction mixture was concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluting with a gradient consisting of 0-20% MeOH in DCM) to give the title compound as a colorless oil (0.04 g). 1H NMR (500 MHz, CD3OD) δ 6.71 (s, 1H), 4.38 (dd, 1H), 3.64 (dd, 1H), 3.48 (dd, 1H), 2.33 (s, 3H), 1.96 (s, 3H).

Provenance & Evidence