Ethyl Acetate → 2-Methylpentane

Participants

Reaction Steps

A solution of tetrabutylammonium fluoride (1M in THF) (8.63 mL, 8.63 mmol) was added in one portion to a stirred solution of (S)-2-(tert-butyldimethylsilyloxy)-3-methoxy-N-(5-methylpyridin-2-yl)propanamide C4d (1.4 g, 4.31 mmol) in THF (20 mL). The resulting solution was stirred at ambient temperature for 4 hours. The reaction mixture was concentrated, diluted with EtOAc (50 mL) and washed sequentially with water (20 mL) and saturated brine (20 mL). The organic layer was dried over MgSO4, filtered and evaporated to afford crude product as an oil. Trituration with 1:1 isohexane:EtOAc afforded (S)-2-hydroxy-3-methoxy-N-(5-methylpyridin-2-yl)propanamide (340 mg). The residue was purified by flash silica chromatography with EtOAc to afford a second batch of (S)-2-hydroxy-3-methoxy-N-(5-methylpyridin-2-yl)propanamide (220 mg).

Provenance & Evidence