Dimethylformamide → HCID 178509669, compound

Participants

Reaction Conditions

Reaction Steps

1-(2-bromophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol B17b (1.456 g, 5 mmol) and zinc cyanide (0.528 g, 4.50 mmol) were dissolved in DMF (15 mL) and sealed into a microwave tube. The tube was evacuated and back flushed with nitrogen several times. 9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene (0.289 g, 0.50 mmol) and tris(dibenzylideneacetone)dipalladium(0) (0.229 g, 0.25 mmol) were added. The reaction was heated to 160° C. for 10 minutes in the microwave reactor and cooled to RT. This was repeated on exactly the same scale. The two reaction mixtures were combined and diluted with EtOAc (200 mL) and water (30 mL). The biphasic mixture was filtered, and the organic phase separated and washed with brine (20 mL) then dried over MgSO4, filtered and evaporated. The residue was purified by hot filtration, then crystallization from MeOH, providing 2-(4-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-1-yl)benzonitrile (1.225 g). 1H NMR (400 MHz, DMSO-d6) δ 7.70-7.75 (1H, m), 7.86-7.88 (1H, m), 7.91-7.95 (1H, m), 8.08-8.10 (1H, m), 8.17 (1H, s), 8.43 (1H, s), 12.49 (1H, s), m/z (ESI+) (M+H)+=238; HPLC tR=1.15 min.

Provenance & Evidence