참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 반응물 | Pyrazine, 2-chloro-3-methyl- | HCID 66769 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Hydrazinyl-3-methylpyrazine | HCID 270702 | 80% |
반응 단계
Hydrazine hydrate (9.66 mL, 311.14 mmol) was added to 2-chloro-3-methylpyrazine (CAS no. 95-58-9) (8 g, 62.23 mmol) in ethanol (25 mL). The resulting solution was stirred at 90° C. for 16 hours. The resulting solution was evaporated to dryness and the crude product was purified by crystallisation from toluene (125 mL) to afford 2-hydrazinyl-3-methylpyrazine (6.2 g, 80%). 1H NMR (400 MHz, DMSO-d6) δ 2.24 (3H, s), 7.61 (1H, d), 7.61 (1H, d), 7.87 (1H, d).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08143263B2 |
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| 출처 데이터셋 | uspto-grants-2012_03 |
|---|
| ORD ID | ord-eba063b6363646cba6df39603f4ff3dc |
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| 출처 메모 | uspto-grants-2012_03 |
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