Tetrabutylammonium Fluoride → (S)-2-hydroxy-3-((S)-1-methoxypropan-2-yloxy)-N-(5-methylpyrazin-2-yl)propanamide

Participants

Reaction Steps

Tetrabutylammonium fluoride (1M in THF) (1199 μl, 1.20 mmol) was added to (S)-2-(tert-butyldimethylsilyloxy)-3-((S)-1-methoxypropan-2-yloxy)-N-(5-methylpyrazin-2-yl)propanamide (Intermediate Y2) (230 mg, 0.60 mmol) in THF (3.0 mL) at 20° C. The resulting solution was stirred at room temperature for 3 hours. The reaction mixture was concentrated and diluted with ethyl acetate (50 mL), and washed sequentially with water (25 mL) and saturated brine (10 mL). The organic layer was dried (MgSO4) and evaporated. The crude product was purified by flash silica chromatography, eluting with 100% ethyl acetate to afford the product (80 mg, 50%). 1H NMR (400 MHz, CDCl3) δ 1.16 (d, 3H), 2.53 (s, 3H), 3.34-3.45 (m, 5H), 3.66-3.81 (m, 2H), 3.97-4.03 (m, 1H), 4.30 (d, 1H), 4.34-4.39 (m, 1H), 8.13 (d, 1H), 9.30 (s, 1H), 9.41 (d, 1H); m/z (ESI+) (M+H)+=270.29; HPLC tR=0.95 min.

Provenance & Evidence