HRID1098196

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57504566

未命名化合物

结构：Cc1ccc(NC(=O)[C@@H](O)COCCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)nc1

HCID57504665

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)[C@H](COCCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)Oc2ncnc3c2cnn3-c2c(Cl)cccc2C#N)nc1

HCID57504530

未命名化合物

PROCEDURE

实验过程

Prepared using a procedure analogous to that described with Intermediate AH7 using (S)-3-(2-(tert-butyldiphenylsilyloxy)ethoxy)-N-(5-methylpyridin-2-yl)-2-hydroxypropanamide (Intermediate AU2) and 3-chloro-2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)benzonitrile (Intermediate AH6). m/z (ES+) (M+H)+=732; HPLC tR=3.76 min

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c9ae12fa4ba54f948e2f25f8a7b7c61f
来源数据集: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08143263B2
来源说明: uspto-grants-2012_03

反应 SMILES

[Si:1]([O:18][CH2:19][CH2:20][O:21][CH2:22][C@H:23]([OH:34])[C:24]([NH:26][C:27]1[CH:32]=[CH:31][C:30]([CH3:33])=[CH:29][N:28]=1)=[O:25])([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:35][C:36]1[C:37]([N:44]2[C:48]3=[N:49][CH:50]=[N:51][C:52](Cl)=[C:47]3[CH:46]=[N:45]2)=[C:38]([CH:41]=[CH:42][CH:43]=1)[C:39]#[N:40]>>[Si:1]([O:18][CH2:19][CH2:20][O:21][CH2:22][C@H:23]([O:34][C:52]1[N:51]=[CH:50][N:49]=[C:48]2[N:44]([C:37]3[C:38]([C:39]#[N:40])=[CH:41][CH:42]=[CH:43][C:36]=3[Cl:35])[N:45]=[CH:46][C:47]=12)[C:24]([NH:26][C:27]1[CH:32]=[CH:31][C:30]([CH3:33])=[CH:29][N:28]=1)=[O:25])([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1