HRID10982

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCC1(C(=O)O)CCc2ncc(NC(=O)OCc3ccccc3)c(=O)n21

HCID21979621

未命名化合物

HCID145832046

未命名化合物

PRODUCTS

生成物

结构：CCC1(C(=O)NCc2ccc(C(=N)NC(=O)OC(C)(C)C)cc2)CCc2ncc(NC(=O)OCc3ccccc3)c(=O)n21

HCID145857217

未命名化合物

收率 100%

PROCEDURE

实验过程

According to the procedure for the preparation of intermediate 19c, intermediate 22b (34.5 mg, 0.0965 mmol) was coupled with [(4-aminomethyl-phenyl)-imino-methyl]-carbamic acid tert-butyl ester to afford 57 mg (100%) of intermediate 22c.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fb6ccc65119b4e95b56e88ab95c1b6e5
来源数据集: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07094783B2
来源说明: uspto-grants-2006_08

反应 SMILES

[CH2:1]([O:8][C:9]([NH:11][C:12]1[C:17](=[O:18])[N:16]2[C:19]([CH2:25][CH3:26])([C:22]([OH:24])=O)[CH2:20][CH2:21][C:15]2=[N:14][CH:13]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:27]([O:31][C:32](=[O:44])[NH:33][C:34]([C:36]1[CH:41]=[CH:40][C:39]([CH2:42][NH2:43])=[CH:38][CH:37]=1)=[NH:35])([CH3:30])([CH3:29])[CH3:28]>>[CH2:1]([O:8][C:9](=[O:10])[NH:11][C:12]1[C:17](=[O:18])[N:16]2[C:19]([C:22](=[O:24])[NH:43][CH2:42][C:39]3[CH:40]=[CH:41][C:36]([C:34]([NH:33][C:32]([O:31][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:44])=[NH:35])=[CH:37][CH:38]=3)([CH2:25][CH3:26])[CH2:20][CH2:21][C:15]2=[N:14][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1