反应详情

温度

100 °C

4,6-Dichloropyrimidin-5-amine (CAS no. 5413-85-4) (2 g, 12.20 mmol) and 2-chloroaniline (CAS no. 95-51-2) (1.556 g, 12.20 mmol) were dissolved in ethylene glycol (12 mL) and sealed into a microwave tube. The reaction was heated to 100° C. for 1 hour in the microwave reactor and cooled to room temperature. The reaction mixture was quenched with water (50 mL), extracted with EtOAc (3×50 mL), the organic layer was dried (MgSO4), filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, eluting with 0 to 60% EtOAc in isohexane to afford the product (2.65 g, 85%). 1H NMR (400 MHz, DMSO) 65.38 (s, 2H), 7.19-7.25 (m, 1H), 7.32-7.38 (m, 1H), 7.49-7.54 (m, 1H), 7.57-7.62 (m, 1H), 7.73 (s, 2H), 7.19-7.25 (s, 1H); m/z (ES+), (M+H)+=255.25; HPLC tR=1.82 min.

1. customsealed into a microwave tube
2. temperaturecooled to room temperature
3. customThe reaction mixture was quenched with water (50 mL)
4. extractionextracted with EtOAc (3×50 mL)
5. dry with materialthe organic layer was dried (MgSO4)
6. filtrationfiltered
7. customevaporated
8. customto afford crude product
9. customThe crude product was purified by flash silica chromatography
10. washeluting with 0 to 60% EtOAc in isohexane