2-Amino-5-chloropyridine → HCID 57504701, compound

Participants

Reaction Conditions

Reaction Steps

Trimethylaluminium (2M solution in toluene) (2.99 mL, 5.98 mmol) was added to a solution of 5-chloropyridin-2-amine (0.769 g, 5.98 mmol) in toluene (20 mL) at 0° C. under nitrogen. The reaction mixture was stirred at 0° C. for 20 mins and then (S)-methyl 2-hydroxy-3-((R)-1-(triisopropylsilyloxy)propan-2-yloxy)propanoate (Intermediate AU5) (1 g, 2.99 mmol) was added. The reaction mixture was allowed to warm to room temperature and then heated at reflux under nitrogen for 4 hours. The reaction mixture was allowed to cool to room temperature and the concentrated in vacuo. The residue was neutralised with citric acid (1M, aq.) and then diluted with water and DCM (50 mL). The organic layer was separated and the aqueous layer re-extracted with DCM (30 mL). The combined organics were dried (MgSO4), filtered and evaporated in vacuo. The crude product was purified by flash silica chromatography, elution gradient 20 to 50% EtOAc in isohexane to afford the product (0.935 g, 72.6%). 1H NMR (400 MHz, CDCl3) δ 1.05-1.13 (24H, m), 3.62-3.67 (3H, m), 3.81-3.84 (1H, m), 4.02-4.06 (1H, m), 4.20 (1H, d), 4.31 (1H, q), 7.65-7.67 (1H, m), 8.22-8.25 (2H, m), 9.23 (1H, s); m/z (ES−) (M−H)−=429; HPLC tR=3.81 min.

Provenance & Evidence