Chloroacetyl chloride → HCID 23156812, compound

Participants

Reaction Steps

0.236 ml (1.69 mmol) of triethylamine and 0.101 ml (1.27 mmol) of chloroacetyl chloride were added in this order to 200 mg (0.85 mmol) of 7-amino-3-phenyl-2H-isoquinolin-1-one obtained in Example 39. The obtained mixture was stirred at a room temperature for 2 hours. Thereafter, 30 ml of 1 N hydrochloric acid was added to the reaction solution, and the mixture was then extracted with methylene chloride (30 ml×2). The extract was dried over anhydrous magnesium sulfate, and the solvent was then distilled away under reduced pressure. The precipitated solid was collected by filtration, and the filtrate was then washed with a suitable amount of ether, so as to obtain 229 mg (86%) of 2-chloro-N-(1-oxo-3-phenyl-1,2-dihydroisoquinolin-7-yl)acetamide in the form of a light brown solid.

Provenance & Evidence