m-Chloroperbenzoic acid → HCID 23156868, compound

Participants

Reaction Conditions

Reaction Steps

20.1 mg (0.0515 mmol) of the 7-thiomorpholin-4-yl-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in Example 104 was dissolved in 2.3 ml of methylene chloride, and 9.8 mg (0.0566 mmol) of m-chloroperbenzoic acid was further added to the solution. The obtained mixture was stirred at 0° C. for 2 hours. Thereafter, a saturated sodium bicarbonate aqueous solution was added to the reaction solution, and the obtained mixture was then extracted with methylene chloride. The extract was dried over anhydrous sodium sulfate, and was then concentrated. The obtained residue was purified by silica gel column chromatography (methylene chloride:methanol=20:1), so as to obtain 16.6 mg (79%) of 7-(1-oxothiomorpholin-4-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one in the form of a light yellow solid.

Provenance & Evidence