2-Bromo-5-methylbenzoic acid → 5-bromo-N,2-dimethylbenzamide

HRID 1098306Notes

Reaction equation

HRID 1098306 reaction equation
BrC1C=CC(C)=CC=1C(O)=O.[Br:12][C:13]1[CH:22]=[C:21]2[C:16]([CH:17]=[C:18](C3C=CC=CC=3C(F)(F)F)[NH:19][C:20]2=[O:23])=[CH:15][CH:14]=1>>[Br:12][C:13]1[CH:14]=[CH:15][C:16]([CH3:17])=[C:21]([CH:22]=1)[C:20]([NH:19][CH3:18])=[O:23]

Participants

3

Reactant 2

HCID 2280802-Bromo-5-methylbenzoic acidHCID 23156787HCID 23156787, compound

Product 1

HCID 231569135-bromo-N,2-dimethylbenzamide

Procedure

5-Bromo-2,N-dimethylbenzamide was prepared by a method similar to that in Step A of Example 1 from 2-bromo-5-methylbenzoic acid that can be prepared by the method disclosed in WO2002/083066 or U.S. Pat. No. 4,282,365. Using this compound as a starting material, 7-bromo-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one was synthesized by a method similar to that in Step B of Example 1.

Workup

  1. customcan be prepared by the method
  2. customwas synthesized by a method similar to that in Step B of Example 1

Sources & evidence

ORD record
ord-d7fc9cb4763246e1b0ee946902e55d87
Source dataset
uspto-grants-2012_03
Patent number
US08143274B2

Reaction notes

Loading…