HCID 58941631, compound → HCID 58941666, compound

Participants

Reaction Steps

4.5 mg of 10% Pd/C was added to a methanol solution (5 ml) containing 44.9 mg (0.093 mmol) of 2-benzyloxyethyl[1-oxo-3-(2-trifluoromethylphenyl)-1,2-dihydroisoquinolin-7-yl]carbamate obtained in Example 130. The obtained mixture was intensively stirred under a hydrogen atmosphere at a room temperature for 2 hours 20 minutes. Thereafter, insoluble matters were removed by filtration, and the filtrate was then concentrated. The obtained residue was purified by silica gel column chromatography (ethyl acetate), so as to obtain 33 mg (90%) of 2-hydroxyethyl[1-oxo-3-(2-trifluoromethylphenyl)-1,2-dihydroisoquinolin-7-yl]carbamate.

Provenance & Evidence