Sodium Bicarbonate → HCID 23156893, compound

Participants

Reaction Steps

0.070 ml (0.070 mmol) of a 1 M boron tribromide dichloromethane solution was added at 0° C. to a dichloromethane solution (0.5 ml) containing 17 mg (0.0466 mmol) of the 7-(3-hydroxypiperidin-1-yl)-3-(4-methoxy-2-methylphenyl)-2H-isoquinolin-1-one obtained in Example 90. The obtained mixture was stirred at the same above temperature for 30 minutes. Thereafter, a saturated sodium bicarbonate aqueous solution was added to the reaction solution, and the mixture was then extracted with dichloromethane/methanol (5:1). The extract was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (dichloromethane:methanol=20:1 to 10:1), so as to obtain 10 mg (61%) of 3-(4-hydroxy-2-methylphenyl)-7-(3-hydroxypiperidin-1-yl)-2H-isoquinolin-1-one in the form of a light brown solid.

Provenance & Evidence