HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Fluoro-3-(propane-1-sulfonylamino)-benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Fluoro-3-(propylsulfonamido)benzoic acid | HCID 58086577 | — |
| Product | 2-Fluoro-3-(propane-1-sulfonylamino)-benzoyl chloride | HCID 58086734 | — |
Reaction Steps
To 2-fluoro-3-(propane-1-sulfonylamino)-benzoic acid (50, 1.17 g, 4.5 mmol) was added thionyl chloride (10.0 mL). The reaction was heated to reflux for 3 hours. The reaction was concentrated to give crude compound 51 that was used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143271B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-31a5471cbd154f6f9c7503a081794e80 |
| Source note | uspto-grants-2012_03 |