5-Chloro-1H-pyrrolo[2,3-b]pyridine → Thiophene-2-sulfonic acid [3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide

Participants

Role	Name	HCID	Charge
Reactant	5-Chloro-1H-pyrrolo[2,3-b]pyridine	HCID 24229213	—
Reactant	N-(2,4-difluoro-3-formylphenyl)propane-2-sulfonamide	HCID 58086031	—
Reactant	Thiophene-2-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide	HCID 58086492	—
Product	Thiophene-2-sulfonic acid [3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide	HCID 58086197	—

Reaction Steps

was prepared using the protocol of Steps 3 and 4 of Scheme 17, substituting 5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridine 89 with 5-chloro-7-azaindole 80 (see Example 9) and propane-2-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide 60 with thiophene-2-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide 512 (see Example 21) in Step 3. MS (ESI) [M+H+]+=451.9.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08143271B2
Source dataset	uspto-grants-2012_03
ORD ID	ord-66d87a44d5e1446bbc916cad0838ab2f
Source note	uspto-grants-2012_03