Thionyl Chloride → HCID 58087452, compound

HRID 1098386Notes

Reaction equation

HRID 1098386 reaction equation
[CH2:1]([S:4]([NH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11](O)=[O:12])(=[O:6])=[O:5])[CH2:2][CH3:3].S(Cl)([Cl:19])=O>>[CH2:1]([S:4]([NH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([Cl:19])=[O:12])(=[O:6])=[O:5])[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 162282623-[(Propane-1-sulfonyl)amino]benzoic acid

Product 1

HCID 58087452HCID 58087452, compound

Procedure

A solution of 3-(propane-1-sulfonylamino)-benzoic acid (76, 1.20 g, 4.93 mmol) in thionyl chloride was heated to reflux for 3.0 hours. Evaporation of the solvent gave compound 77 as white solid that was used for the next step.

Workup

  1. temperatureto reflux for 3.0 hours
  2. customEvaporation of the solvent

Sources & evidence

ORD record
ord-71a51daeba604277a775a39195617aa3
Source dataset
uspto-grants-2012_03
Patent number
US08143271B2

Reaction notes

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