HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1098467Generated: October 26, 2026
Hydrochloric Acid → 5-(4-chloro-benzyloxy)-2-hydroxymethyl-1H-pyridin-4-one
https://huagongshe.com/reaction/1098467
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 5-(4-Chloro-benzyloxy)-2-hydroxymethyl-pyran-4-one | HCID 58086834 | — |
| Product | 5-(4-chloro-benzyloxy)-2-hydroxymethyl-1H-pyridin-4-one | HCID 58087564 | — |
Reaction Steps
5-(4-Chloro-benzyloxy)-2-hydroxymethyl-pyran-4-one (638, 8.00 g, 3.00 mmol) was suspended in ammonium hydroxide (200 mL) in an 80 mL sealed tube. The reaction was heated at 90° C. overnight. Upon cooling, the reaction was lowered to pH 10 with 6N HCl to provide a beige solid that was collected by filtration (639, 7.8 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08143271B2 |
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| Source dataset | uspto-grants-2012_03 |
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| ORD ID | ord-e8e49df86dd3416f8f2dc14ea04abae1 |
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| Source note | uspto-grants-2012_03 |
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