HRID10985

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COCC1(C(=O)O)CCc2ncc(NC(=O)OCc3ccccc3)c(=O)n21

HCID21979643

未命名化合物

HCID145832046

未命名化合物

PRODUCTS

生成物

结构：COCC1(C(=O)NCc2ccc(C(=N)NC(=O)OC(C)(C)C)cc2)CCc2ncc(NC(=O)OCc3ccccc3)c(=O)n21

HCID145857230

未命名化合物

收率 100%

PROCEDURE

实验过程

According to the procedure for the preparation of intermediate 19c, intermediate 23b (57.8 mg, 0.155 mmol) was coupled with [(4-aminomethyl-phenyl)-imino-methyl]-carbamic acid tert-butyl ester to afford 94 mg (100%) of intermediate 23c.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e044293813a0477f8e6f434a4d06c847
来源数据集: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07094783B2
来源说明: uspto-grants-2006_08

反应 SMILES

[CH2:1]([O:8][C:9]([NH:11][C:12]1[C:17](=[O:18])[N:16]2[C:19]([CH2:25][O:26][CH3:27])([C:22]([OH:24])=O)[CH2:20][CH2:21][C:15]2=[N:14][CH:13]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:28]([O:32][C:33](=[O:45])[NH:34][C:35]([C:37]1[CH:42]=[CH:41][C:40]([CH2:43][NH2:44])=[CH:39][CH:38]=1)=[NH:36])([CH3:31])([CH3:30])[CH3:29]>>[CH2:1]([O:8][C:9](=[O:10])[NH:11][C:12]1[C:17](=[O:18])[N:16]2[C:19]([C:22](=[O:24])[NH:44][CH2:43][C:40]3[CH:41]=[CH:42][C:37]([C:35]([NH:34][C:33]([O:32][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:45])=[NH:36])=[CH:38][CH:39]=3)([CH2:25][O:26][CH3:27])[CH2:20][CH2:21][C:15]2=[N:14][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1