HCID 66728944, compound → 5-(Propan-2-yl)pyridin-3-amine

To a solution of 5-(prop-1-en-2-yl)pyridin-3-amine (0.773 g, 2.48 mmol) in ethanol (8 mL) was added 10% Pd/C (0.132 g, 0.124 mmol) and the resulting suspension was stirred under a hydrogen atmosphere (1 atm) for 18 h. The reaction was filtered through Celite® and washed forward with EtOH. The filtrate was concentrated, diluted with EtOAc (30 mL) and washed with H2O (1×15 ml) and brine (1×15 ml). The aqueous phase was back-extracted with EtOAc (1×20 ml). The combined organic layers were dried (MgSO4) and concentrated to afford 5-isopropylpyridin-3-amine (0.453 g, 134%) as a light yellow oil. MS (ESI) m/z: 137.1 (M+H+).

1. filtrationThe reaction was filtered through Celite®
2. washwashed forward with EtOH
3. concentrationThe filtrate was concentrated
4. additiondiluted with EtOAc (30 mL)
5. washwashed with H2O (1×15 ml) and brine (1×15 ml)
6. extractionThe aqueous phase was back-extracted with EtOAc (1×20 ml)
7. dry with materialThe combined organic layers were dried (MgSO4)
8. concentrationconcentrated

ORD record

ord-132e49140dad42fab7c464c6af402992

Source dataset

uspto-grants-2012_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08143293B2