反应详情

To a mixture of acid 1i (4.50 g, 13.7 mmol) in 70 mL THF at 0° C., was added 3-(trifluoromethyl)benzyl bromide (8.35 mL, 54.7 mmol), NaH (60% dispersion in oil, 1.64 g, 41.4 mmol), and TBAI (100 mg, catalytic). The reaction was stirred at rt for 15 h, then quenched with the addition of 50 mL H2O. The volatile solvents were removed by rotary evaporation and the aqueous solution obtained was partitioned with Et2O. The organic phase was extracted with 20% sat. NaHCO3 (3×). The combined aqueous extract was acidified with 1N HCl and extracted with EtOAc (5×). The combined organic extract was washed (brine), dried (Na2SO4), and concentrated to afford 6.18 g (93%) of the 3-(trifluoromethyl)benzyl amine (25a), which was used in the following step without additional purification. MS (ESI) 488.3 (M+H+), 510.3 (M+Na+); 486.3 (M−H+).

1. customquenched with the addition of 50 mL H2O
2. customThe volatile solvents were removed by rotary evaporation
3. customthe aqueous solution obtained
4. customwas partitioned with Et2O
5. extractionThe organic phase was extracted with 20% sat. NaHCO3 (3×)
6. extractionThe combined aqueous extract
7. extractionextracted with EtOAc (5×)
8. extractionThe combined organic extract
9. washwas washed (brine)
10. dry with materialdried (Na2SO4)
11. concentrationconcentrated