反应详情

To a solution of N-[1-(3-Pentafluoroethyl-phenyl)-vinyl]-acetamide (110 mg, 0.39 mmol) in methanol (10 ml) was added (+)-1,2-bis((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium (I) trifluoromethanesulfonate (0.3 mg). The reaction mixture was hydrogenated with H2 at 5 bar and evaporated. The residue was dissolved in ethanol and hydrochloric acid (6 M, 0.7 ml) and the solution was refluxed for 2 days. Purification by preparative HPLC and lyophilization of the relevant fractions gave the desired product.

1. customevaporated
2. dissolutionThe residue was dissolved in ethanol
3. temperaturehydrochloric acid (6 M, 0.7 ml) and the solution was refluxed for 2 days
4. customPurification by preparative HPLC and lyophilization of the relevant fractions