Water → HCID 59506304, compound

Participants

Reaction Steps

To a solution of the product obtained from step 2 (4.80 g, 16.15 mmol) in methanol (80 ml) and tetrahydrofurane (80 ml) was added drop wise to a solution of oxone, monopersulfate compound (17.87 g, 29.07 mmol) in water (80 ml) at 0° C. The suspension was stirred 4 days at RT. Water (100 ml) was added and the reaction mixture was extracted with DCM. The combined organic phases were washed with brine and dried over magnesium sulphate. Evaporation and purification of the crude product by silica gel chromatography using DCM/methanol=20:1 gave the desired product (2.80 g, 53%).

Provenance & Evidence