Methanol → HCID 59506145, compound

Participants

Reaction Steps

To a solution of the compound yielded from step 4 (160 mg, 0.51 mmol) in MeOH (3 mL) ammonium acetate (395 mg, 5.13 mmol) and sodium cyanoborohydride (32 mg, 0.513 mmol) were added. The reaction mixture was refluxed for 3 h. Then the mixture was quenched by addition of trifluoroacetic acid (pH=2) and evaporated to dryness. Purification of the crude product by prep-HPLC and lyophilization of the relevant fractions leads to the desired product.

Provenance & Evidence