Hydrochloric Acid → HCID 59506249, compound

Participants

Reaction Steps

To a solution of the product obtained in step 1 (4.8 g, 12.5 mmol) in ACN (15 ml) was added Cul (119 mg, 0.62 mmol), PdCl2(PPh3)2 and 1-(ethoxyvinyl)tributyl-stannane (5.4 g, 14.95 mmol). The mixture was refluxed for 3 h. After cooling, the reaction mixture was acidified with 1 N HCl (7 ml) and stirred for 20 min. The reaction mixture was neutralized with saturated aqueous NaHCO3 and extracted with AcOEt. The organic phase was dried over Na2SO4 and evaporated. Purification of the crude product by silica gel chromatography using ethyl acetate/n-heptane gave the desired product (2.95 g, 68%).

Provenance & Evidence