Methanol → HCID 59506268, compound

Participants

Reaction Steps

To a solution of the compound yielded from step 3 (2.2 g, 5.7 mmol) in MeOH (30 mL) ammonium acetate (4.39 g, 57.0 mmol) and sodium cyanoborohydride (358 mg, 5.7 mmol) were added. The reaction mixture was refluxed for 4 h. After that the mixture was acidified with trifluoroacetic acid to pH=2 and then evaporated to dryness. Purification of the crude product by prep-HPLC and lyophilization of the relevant fractions gave the desired product (0.96g, 34%).

Provenance & Evidence