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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1098841Generated: November 1, 2026

(2RS,3RS)-3-amino-1-phenoxy-butan-2-ol → (2RS,3RS)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenoxy-butan-2-amine

https://huagongshe.com/reaction/1098841

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2RS,3RS)-3-amino-1-phenoxy-butan-2-olHCID 15105310—
Reactant1-(4-fluorophenyl)-5-iodo-1H-indazoleHCID 59251128—
Product(2RS,3RS)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenoxy-butan-2-amineHCID 66812100—

Reaction Steps

Prepared as described in Example 1 from (2RS,3SR)-3-amino-1-phenoxy-butan-2-ol (319 mg, 1.75 mmol), and 1-(4-fluorophenyl)-5-iodoindazole (710 mg, 2.10 mmol). Yield 244 mg (36%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08143290B2
Source datasetuspto-grants-2012_03
ORD IDord-e6bda66283f349b7afc506419972abcc
Source noteuspto-grants-2012_03