反应详情

1-(4-Fluorophenyl)-6-chloro-5-methoxy-1H-indazole (99d) (0.91 mmol, 253 mg) was dissolved in dichloromethane (4 mL) and BBr3 (4 mL, 1 M/CH2Cl2) was added. The reaction mixture was stirred in room temperature overnight before it was quenched with water (20 mL). The product was extracted with dichloromethane (2×20 mL) and washed with sat NaHCO3. The organic phase was dried over Na2SO4, concentrated and purified by flash chromatography on silica gel (heptane-ethyl acetate). Yield: 219 mg (91%).

1. customwas quenched with water (20 mL)
2. extractionThe product was extracted with dichloromethane (2×20 mL)
3. washwashed
4. dry with materialThe organic phase was dried over Na2SO4
5. concentrationconcentrated
6. custompurified by flash chromatography on silica gel (heptane-ethyl acetate)