反应详情

(αS,βR)-β-{[1-(4-Fluorophenyl)-1H-indazole-5-yl]oxy}-α-methylbenzeneethanamine (50 mg, 0.14 mmol), as described in Example 1, is dissolved in 0.89 mL dichloromethane and furylmethylisothiocyanate (19.3 mg, 0.14 mmol) is dropwise added. After stirring for 90 min at r.t. water (5 mL) is added and the reaction mixture extracted once with ethyl acetate (50 mL). The organic phase is washed with water (10 mL) and dried over Na2SO4. After filtration the solvent is removed and the residue purified by chromatography (silicagel, eluents: hexane/ethylacetate). 53.8 mg (77.7%) of the title compound are obtained.

1. additionis added
2. extractionthe reaction mixture extracted once with ethyl acetate (50 mL)
3. washThe organic phase is washed with water (10 mL)
4. dry with materialdried over Na2SO4
5. filtrationAfter filtration the solvent
6. customis removed
7. customthe residue purified by chromatography (silicagel, eluents: hexane/ethylacetate)