Acetone → HCID 145857224, compound

Participants

Role	Name	HCID	Charge
Reactant	Acetone	HCID 180	—
Reactant	Sodium triacetoxyborohydride	HCID 5049666	—
Reactant	benzyl N-[(6S,8R)-8-amino-8-methyl-4-oxo-6-[[4-(N-phenylmethoxycarbonylcarbamimidoyl)phenyl]methylcarbamoyl]-6,7-dihydropyrrolo[1,2-a]pyrimidin-3-yl]-N-prop-2-enylcarbamate	HCID 145857227	—
Reactant	tert-butyl N-[4-[[[(6S)-3-(benzylamino)-4-oxo-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carbonyl]amino]methyl]benzenecarboximidoyl]carbamate	HCID 145857234	—
Product	HCID 145857224	HCID 145857224	28.1%

Reaction Steps

Following a procedure similar to that for the preparation of intermediate 1k, 26a (30 mg, 0.045 mmol), acetone (5.3 mg, 0.090 mmol) and NaBH(OAc)3 (26.8 mg, 0.127 mmol) yielded 8.9 mg (28.1%) of 27a. MS (ESI) 706.2 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07094783B2
Source dataset	uspto-grants-2006_08
ORD ID	ord-6ece1c29cc1b4b1eab7b6792a465b241
Source note	uspto-grants-2006_08