HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | methyl 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetate | HCID 59339649 | — |
| Product | 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetamide | HCID 59339722 | — |
Reaction Steps
A suspension of methyl 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetate (137c, 75 mg, 200 μmol) in methanolic NH3 (7 M, 1 ml) was stirred at r.t. overnight to give a clear solution. Then the solvent was removed in vacuo, and the crude product was freeze-dried go give white solid material, 60 mg (83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143290B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-1f4c560bce3740a9ac3af0765c852a8b |
| Source note | uspto-grants-2012_03 |