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HRID1098953

反应详情

EQUATION

反应方程式

HRID 1098953 的结构方程式

REACTANTS

反应物

1
结构：COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)NC(=O)CNC(N)=O)c1
HCID59339658

未命名化合物

PRODUCTS

生成物

1
结构：COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)N2C(=O)CNC2=O)c1
HCID44595798

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

CONDITIONS

反应条件

温度
120 °C

PROCEDURE

实验过程

2-(carbamoylamino)-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide (270, 141 mg, 0.29 mmol) was dissolved in acetic acid (3 mL). The reaction was heated at 120° C. with stirring for 20 h. The HOAc was evaporated and the product was purified by preparative HPLC.

WORKUP

后处理

  1. customThe HOAc was evaporated
  2. customthe product was purified by preparative HPLC