2-(carbamoylamino)-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide → HCID 44595798、化合物

HRID 1098953ノート

反応式

HRID 1098953 の反応式
[C:1]([NH:4][CH2:5][C:6]([NH:8][C@@H:9]([CH3:36])[C@H:10]([O:19][C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[N:25]([C:29]1[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=1)[N:24]=[CH:23]2)[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=1)=[O:7])(=[O:3])N>C(O)(=O)C>[F:35][C:32]1[CH:33]=[CH:34][C:29]([N:25]2[C:26]3[C:22](=[CH:21][C:20]([O:19][C@H:10]([C:11]4[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=4)[C@@H:9]([N:8]4[C:6](=[O:7])[CH2:5][NH:4][C:1]4=[O:3])[CH3:36])=[CH:28][CH:27]=3)[CH:23]=[N:24]2)=[CH:30][CH:31]=1

参加物

3

反応物 1

HCID 593396582-(carbamoylamino)-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide

生成物 1

HCID 44595798HCID 44595798、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
120 °C

実験手順

2-(carbamoylamino)-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide (270, 141 mg, 0.29 mmol) was dissolved in acetic acid (3 mL). The reaction was heated at 120° C. with stirring for 20 h. The HOAc was evaporated and the product was purified by preparative HPLC.

後処理

  1. customThe HOAc was evaporated
  2. customthe product was purified by preparative HPLC

出典と根拠

ORDレコード
ord-2d4c05715e2349e7a7dc9ca064709663
出典データセット
uspto-grants-2012_03
特許番号
US08143290B2

反応ノート

読み込み中…