HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid methylene chloride → (r)-2-Amino-n-((1r,2s)-1-(1-(4-fluorophenyl)-1h-indazol-5-yloxy)-1-(3-methoxyphenyl)propan-2-yl)propanamide trifluoroacetic acid salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Reactant | Tert-butyl (R)-1-((1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-(3-methoxyphenyl)propan-2-ylamino)-1-oxopropan-2-ylcarbamate | HCID 59339646 | — |
| Product | (r)-2-Amino-n-((1r,2s)-1-(1-(4-fluorophenyl)-1h-indazol-5-yloxy)-1-(3-methoxyphenyl)propan-2-yl)propanamide trifluoroacetic acid salt | HCID 66812912 | — |
Reaction Steps
Tert-butyl (R)-1-((1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-(3-methoxyphenyl)propan-2-ylamino)-1-oxopropan-2-ylcarbamate (303a, 25 mg, 0.04 mmol) in DCM/TFA 1:1 (1 ml) was shaken for 1 h and then evaporated. Yield 25 mg (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143290B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-ad6d45d06049423699a202ab2b9fead6 |
| Source note | uspto-grants-2012_03 |