Hydrazine → HCID 59216351, compound

HRID 1099026Notes

Reaction equation

HRID 1099026 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]([O:14]C)=O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[NH2:16][NH2:17]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]([NH:16][NH2:17])=[O:14])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 9321HydrazineHCID 13707544Methyl 1-(4-methoxyphenyl)-cyclopropanecarboxylate

Product 1

HCID 59216351HCID 59216351, compoundYield 83%

Conditions

Temperature
120 °C

Procedure

A mixture of methyl 1-(4-methoxyphenyl)cyclopropanecarboxylate (0.90 g, 4.4 mmol) and hydrazine (0.65 mL, 21 mmol) was heated at 120° C. for 2 h. After cooling, the excess hydrazine was removed under reduced pressure. The residue was treated with water, filtered and washed with water to give the desired product (750 mg, 83%). Analytical LCMS: (M+H)+=207.1.

Workup

  1. temperatureAfter cooling
  2. customthe excess hydrazine was removed under reduced pressure
  3. additionThe residue was treated with water
  4. filtrationfiltered
  5. washwashed with water

Sources & evidence

ORD record
ord-84f0b5683e2c429799fc3a50f43247ed
Source dataset
uspto-grants-2012_03
Patent number
US08143251B2

Reaction notes

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