Hydrazine → HCID 59216295, compound

HRID 1099028Notes

Reaction equation

HRID 1099028 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]3O[C:15]([NH2:17])=[N:14][N:13]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[NH2:18][NH2:19]>O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]3[N:18]([NH2:19])[C:15]([NH2:17])=[N:14][N:13]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 592162905-[1-(4-Methoxyphenyl)cyclopropyl]-1,3,4-oxadiazol-2-amine

Product 1

HCID 59216295HCID 59216295, compoundYield 47.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
190 °C

Procedure

A mixture of 5-[1-(4-methoxyphenyl)cyclopropyl]-1,3,4-oxadiazol-2-amine (0.60 g, 2.6 mmol), and hydrazine (0.64 mL, 20 mmol) in water (2.0 mL) was heated at 190° C. for 3 h. After cooling to RT, the mixture was further cooled with ice-water. The crystalline solid formed was collected by filtration, washed with water, and dried under high vacuum to yield the desired product (300 mg, 47.1%). Analytical LCMS: (M+H)+=246.1.

Workup

  1. temperatureAfter cooling to RT
  2. customThe crystalline solid formed
  3. filtrationwas collected by filtration
  4. washwashed with water
  5. customdried under high vacuum

Sources & evidence

ORD record
ord-aa51eaead1b9426999e80cf49b01e943
Source dataset
uspto-grants-2012_03
Patent number
US08143251B2

Reaction notes

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